Brand: Erweka | Category: Scientific & Laboratory Equipment
Erweka's DFZ II flow through cell tester covers a wide range of applications thanks to the variety of cell types available, including testing of poorly soluble products and low dose sustained release formulations. A cell design with increased leak tightness and an optimised tubing system with quick locks let tests be prepared and run quickly. The standardised cell head fits every cell body on offer and, with flat gaskets reduced to three parts per cell, handling and installation are simplified. Cell bodies have reduced wall thickness for improved warming and each cell can be heated individually via a rotary switch. All USP 4 DFZ II systems are controlled through a controller running Disso.NET 3.X software.
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The DRT tests in vitro release of substances from chewing gums and other dosage forms that have to be masticated into the surrounding liquid medium. Vertical up and down strokes of the lower jaw combine with a revolving movement of the upper jaw to give ideal mastication of the gum and simultaneous agitation of the test medium. For manual sampling, emptying and cleaning, the lower jaw with the test cell lowers so that the chewing process stops, after which the test cell and both jaws lift out easily. A water circulation system regulates the water temperature in the test cell around the media. The modular design allows any number of gums to be tested, with 6 test stations the most commonly used, and cells can take extra accessories to measure chewing gum pressure, torque at shear force, pH value and temperature.
The RRT 10 automates dissolution testing for extended and sustained release dosage forms and is suited to simulating the pH changes within the human body. Placing a different medium in each row lets the instrument mirror varying gastrointestinal conditions in vivo, and automatic sample transport between rows supports reliable release testing across different pH zones. Erweka supply it as a USP method 3 device, a USP method 7 device, or a combination of both, with an external flow through heater that minimises vibration and a detachable touch display. Vessels sit in an acrylic water bath with an outlet valve for cleaning, and an automatic cover system reduces evaporation of the media.
The MediPrep 820 prepares up to 8 litres of dissolution media in under 15 minutes, while the MediPrep 1622 takes just 25 minutes and is three times faster than manual preparation to USP. Media are mixed, heated, degassed and gravimetrically filled into vessels in a single pass, and foaming media such as SDS can be handled. Filling runs through the integrated dosing connection or directly into containers with the optional remote filling hand. The MediPrep 1622 adds two inlets for premixed media and a waste water outlet, together with an integrated automatic cleaning process that prevents cross contamination.